Self-assembly of ionic-complementary peptides: a physicochemical viewpoint

被引:108
作者
Chen, P [1 ]
机构
[1] Univ Waterloo, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada
关键词
self-assembly; peptides; ionic-complementarity; electrostatic interactions; amino acid sequence; secondary structure; nanostructure; nanofibers; nanotechnology; nanobiotechnology;
D O I
10.1016/j.colsurfa.2004.12.048
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A major focus in the current development in nanotechnology and biotechnology is to find suitable molecular materials that are amenable to engineering design. Self-assembling, ionic-complementary peptides have recently emerged as one of the most promising biomolecular materials. We provide a brief review of recent research on these newly discovered peptides from a physicochemical point of view. This new class of peptides has a unique molecular structure of alternating positive and negative charge distributions, leading to ionic-complementarity. In addition to hydrogen bonding and hydrophobic interaction, the ionic-complementarity contributes to peptide self-assembly. These peptides assume P-sheet secondary structure predominantly, and can further self-assemble into fibrils, membranes, and even hydrogels with an increase in peptide concentration or other physicochemical parameters. The self-assembly process is highly dependent on the peptide sequence, concentration, pH. presence of salts, and time (or kinetics). By varying these experimentally controllable factors, nanoscopic and/or macroscopic structures with great stability and functionality can be constructed. These nano/microstructures have various biomedical applications, including tissue engineering, drug/gene delivery and biological surface patterning. It is anticipated that molecular engineering of these ionic-complementary peptides will contribute in a significant way to the development of novel nanobiomaterials, and play air important role in the advance of rapidly emerging bionanotechnology fields. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:3 / 24
页数:22
相关论文
共 50 条
  • [31] Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size
    Hu, Kuan
    Xiong, Wei
    Sun, Chengjie
    Wang, Chan
    Li, Jingxu
    Yin, Feng
    Jiang, Yixiang
    Zhang, Ming-Rong
    Li, Zhou
    Wang, Xinwei
    Li, Zigang
    CCS CHEMISTRY, 2020, 2 (01): : 42 - 51
  • [32] Construction of Nano biomolecular Systems by Self-assembly of DNAs and Peptides
    Matsuura, Kazunori
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2010, 68 (04) : 378 - 386
  • [33] Improved stability and selectivity of lytic peptides through self-assembly
    Tu, Zhigang
    Ha, Jumin
    Kharldia, Riddhi
    Meng, Xiao G.
    Liang, Jun F.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 361 (03) : 712 - 717
  • [34] Self-Assembly in Peptides Containing β-and γ-amino Acids
    Shankar, Sudha
    Rahim, Junaid Ur
    Rai, Rajkishor
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2020, 21 (06) : 584 - 597
  • [35] Enzyme-instructed self-assembly (EISA) assists the self-assembly and hydrogelation of hydrophobic peptides
    Li, Xinxin
    Wang, Youzhi
    Zhang, Yiming
    Yang, Zhimou
    Gao, Jie
    Shi, Yang
    JOURNAL OF MATERIALS CHEMISTRY B, 2022, 10 (17) : 3242 - 3247
  • [36] Influence of self-assembly on the performance of antimicrobial peptides
    Haffner, Sara Malekkhaiat
    Malmsten, Martin
    CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2018, 38 : 56 - 79
  • [37] Influence of Structural Features on the Self-Assembly of Short Ionic Oligopeptides
    Desii, Andrea
    Chiellini, Federica
    Duce, Celia
    Ghezzi, Lisa
    Monti, Susanna
    Tine, Maria R.
    Solaro, Roberto
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2010, 48 (04) : 889 - 897
  • [38] Supramolecular self-assembly of polypseudorotaxanes in ionic liquid
    Jing, Bo
    Chen, Xiao
    Hao, Jingcheng
    Qiu, Huayu
    Chai, Yongcun
    Zhang, Guodong
    COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2007, 292 (01) : 51 - 55
  • [39] Effect of temperature on self-assembly of an ionic tetrapeptide
    M. R. Tiné
    M. Alderighi
    C. Duce
    L. Ghezzi
    R. Solaro
    Journal of Thermal Analysis and Calorimetry, 2011, 103 : 75 - 80
  • [40] Effect of temperature on self-assembly of an ionic tetrapeptide
    Tine, M. R.
    Alderighi, M.
    Duce, C.
    Ghezzi, L.
    Solaro, R.
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2011, 103 (01) : 75 - 80