Combination Therapy with Glucan and Coenzyme Q10 in Murine Experimental Autoimmune Disease and Cancer

Background/Aim: Coenzyme Q(10) is a well-accepted anti-oxidant agent known to play a protective role in various physiological and disease processes. Recently, Coenzyme Q(10) is gaining attention as a substance with significant antiinflammatory properties. beta-Glucan is the most studied immunomodulator with significant synergetic effects with numerous bioactive molecules. We aimed to evaluate the possible synergistic effects of simultaneous use of coenzyme Q(10) with the well-established immune modulator, beta-glucan, on immune reactions and cancer development. Materials and Methods: Coenzyme Q(10) and beta-glucan were used, both in vivo and in vitro, and their effects were evaluated using phagocytosis and cytokine secretion. Results: Our study confirmed the strong antiinflammatory effects of coenzyme Q(10) and showed that these effects were further potentiated with the addition of beta-glucan. The anticancer effects of coenzyme Q(10) were less pronounced, but stronger, with the addition of beta-glucan. Conclusion: There is significant synergy between coenzyme Q(10) and beta-glucan.