Detection of the serological markers hepatitis B virus surface antigen (HBsAg) and hepatitis B core IgM antibody (anti-HBcIgM) in the diagnosis of acute hepatitis B virus infection after recent exposure

被引：15
作者：
de Almeida Ponde, Roberio Amorim [1 ,2 ]
机构：
[1] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Lab Human Virol, Goiania, Go, Brazil
[2] Coordenacao Anal & Pesquisas CAP, Gerencia Vigilancia Epidemiol GVE, Superintendencia Vigilancia Saude SUVISA GO, Secretaria Estado Saude SES, Goiania, Go, Brazil
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2022年 / 66卷 / 01期
关键词：
acute HBV infection; anti-HBcIgM; anti-HBe antibodies; HBsAg; HBV exposure; hepatitis B virus; ACUTE EXACERBATION; ESCAPE MUTATIONS; ASSAYS; DETERMINANT; MUTANTS; SEROCLEARANCE; PREVALENCE; PROFILES; COMMON;
D O I：
10.1111/1348-0421.12943
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The serological diagnosis of acute hepatitis B virus (HBV) infection after recent exposure has been established by the hepatitis B virus surface antigen (HBsAg) and anti-hepatitis B core IgM antibody (anti-HBcIgM) detection in serum, sometimes accompanied by the detection of hepatitis B "e" antigen (HBeAg). Despite this characteristic serological profile, misdiagnosis can occur in cases of unexpected or atypical behavior of the serological markers in the bloodstream, or if the true meaning of its expression is not properly investigated, or even if there is a possibility of interference from factors not necessarily linked to the infectious process, in the detection of these markers. This review discusses the influence of these variables on laboratory results for these two serological markers and, therefore, the potential risk of these variables compromising the correct diagnosis of acute infection after recent HBV exposure.
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页码：1 / 9
页数：9
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