Mediation of calcitonin gene-related peptide in protection of ischemic preconditioning in at hindlimbs

被引：0

作者：

Zhou, FW ^{[1
]}

Li, YJ ^{[1
]}

Deng, HW ^{[1
]}

机构：

[1] Hunan Med Univ, Dept Pharmacol, Changsha 410078, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 1998年 / 19卷 / 05期

关键词：

calcitonin gene-related peptide; capsaicin; acetylcholine; phenylephrine; norepinephrine; vasodilation; reperfusion injury;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AIM: To study modulation of calcitonin gene-related peptide (CGRP) in the protective effect of ischemic preconditioning on endothelial cells. METHODS: Rat hindlmbs were subjected to ischemia for 2 h, and endothelium-dependent vasorelaxation to acetylcholine (ACh) was examined in rat hindlimbs. RESULTS: Two hours of ischemia elicited no effect on vasoconstrictor responses to norepinephrine, but markedly impaired vasodilator responses to ACh. Ischemic preconditioning induced by 5-min aortic occlusion and 10-min blood reperfusion prevented the impairment of vasorelaxation to ACh due to long-term ischemia. The protection of ischemic preconditioning was abolished by repeated pretreatments with capsaicin to deplete CGRP. Acute application of capsaicin to evoke CGRP release or CGRP caused an ischemic preconditioning-like protection, CONCLUSION: Cap: saicin-sensitive sensory nerves are involved in the protective effect of ischemic preconditioning on endothelial cells in the rat hindlimbs, and CGRP can mimic the protective effect of ischemic preconditioning in blood vessels.

引用

页码：477 / 480

页数：4