PROGNOSTIC CELL BIOLOGICAL MARKERS IN CERVICAL CANCER PATIENTS PRIMARILY TREATED WITH (CHEMO)RADIATION: A SYSTEMATIC REVIEW

被引：69
作者：
Noordhuis, Maartje G. [1 ]
Eijsink, Jasper J. H. [1 ]
Roossink, Frank [1 ]
de Graeff, Pauline [1 ]
Pras, Elisabeth [2 ]
Schuuring, Ed [3 ]
Wisman, G. Bea A. [1 ]
de Bock, Geertruida H. [4 ]
van der Zee, Ate G. J. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Gynecol Oncol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, NL-9700 RB Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, NL-9700 RB Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2011年 / 79卷 / 02期
关键词：
Cervical cancer; Cell biological markers; Chemoradiation; Response; Prognosis; GROWTH-FACTOR-RECEPTOR; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; RECEIVING RADICAL RADIOTHERAPY; LOCALLY ADVANCED-CARCINOMA; RADIATION-THERAPY; UTERINE CERVIX; CYCLOOXYGENASE-2; INHIBITOR; HUMAN-PAPILLOMAVIRUS; INTRINSIC MARKER; TUMOR OXYGEN;
D O I：
10.1016/j.ijrobp.2010.09.043
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to systematically review the prognostic and predictive significance of cell biological markers in cervical cancer patients primarily treated with (chemo)radiation. A PubMed, Embase, and Cochrane literature search was performed. Studies describing a relation between a cell biological marker and survival in >= 50 cervical cancer patients primarily treated with (chemo)radiation were selected. Study quality was assessed, and studies with a quality score of 4 or lower were excluded. Cell biological markers were clustered on biological function, and the prognostic and predictive significance of these markers was described. In total, 42 studies concerning 82 cell biological markers were included in this systematic review. In addition to cyclooxygenase-2 (COX-2) and serum squamous cell carcinoma antigen (SCC-ag) levels, markers associated with poor prognosis wen, involved in epidermal growth factor receptor (EGFR) signaling (EGER and C-erbB-2) and in angiogenesis and hypoxia (carbonic anhydrase 9 and hypoxia-inducible factor-1 alpha). Epidermal growth factor receptor and C-erbB-2 were also associated with poor response to (chemo)radiation. In conclusion, EGFR signaling is associated with poor prognosis and response to therapy in cervical cancer patients primarily treated with (chemo)radiation, whereas markers involved in angiogenesis and hypoxia, COX-2, and serum SCC-ag levels are associated with a poor prognosis. Therefore, targeting these pathways in combination with chemoradiation may improve survival in advanced-stage cervical cancer patients. (C) 2011 Elsevier Inc.
引用
收藏
页码：325 / 334
页数：10
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