Neurodevelopmental outcomes following necrotizing enterocolitis

被引：71
作者：
Hickey, Marie [1 ]
Georgieff, Michael [2 ,3 ]
Ramel, Sara [1 ]
机构：
[1] Univ Minnesota, Dept Pediat, Div Neonatol, East Bldg,MB630,2450 Riverside Ave, Minneapolis, MN 55454 USA
[2] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Ctr Neurobehav Dev, Div Neonatol, Minneapolis, MN USA
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2018年 / 23卷 / 06期
关键词：
Necrotizing enterocolitis; Outcomes; Neurodevelopment; Prematurity; Nutrition; Inflammation; Gastrointestinal microbiota; BIRTH-WEIGHT INFANTS; EXTREMELY PRETERM INFANTS; GROWTH-FACTOR-I; FAT-FREE MASS; BRAIN-DEVELOPMENT; POSTNATAL SEPSIS; LINEAR GROWTH; MICROBIOTA; INJURY; AXIS;
D O I：
10.1016/j.siny.2018.08.005
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Necrotizing enterocolitis (NEC), a gastrointestinal emergency predominantly affecting premature infants, is associated with increased risk for poor neurodevelopmental outcomes. NEC often strikes during a period of rapid and dynamic neurologic development when the brain is particularly vulnerable to insults and nutrient deficits. The pathogenesis of neurodevelopmental impairment following NEC is likely multifactorial, with both nutritional and non-nutritional factors at play. Follow-up testing that ensures early detection and intervention for impairments is crucial to optimize neurodevelopmental outcomes following NEC. A multifaceted approach to follow-up after NEC is necessary, with close monitoring of growth, serial developmental assessments, neurologic examinations, hearing and vision testing and neuroimaging. Further research is needed to understand the pathogenesis of neurodevelopmental impairment following NEC, to identify more targeted follow-up tests, and to discover interventions aimed at optimizing neurodevelopmental outcomes following NEC.
引用
收藏
页码：426 / 432
页数：7
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