Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions

被引：80

作者：

Tian, Li ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Hu, Xiu-Qin ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 05期

关键词：

aminocatalysis; catalytic cascade reactions; hydrogen-bonding catalysis; ion-pairing catalysis; quaternary centers; DIELS-ALDER REACTION; ASYMMETRIC STRECKER REACTION; 4 CONTIGUOUS STEREOCENTERS; PHASE-TRANSFER CATALYSIS; MICHAEL-MICHAEL CASCADE; ENANTIOSELECTIVE CONSTRUCTION; DOMINO REACTIONS; ALPHA; BETA-UNSATURATED KETONES; SPIROOXINDOLE DERIVATIVES; ORGANOCASCADE CATALYSIS;

D O I：

10.1002/ajoc.201500486

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quaternary carbon stereocenters are present in a wide variety of organic compounds and drug molecules. Highly enantioselective construction of such quaternary carbon stereocenters has received considerable attention owing to the great challenges in their syntheses. With the development of asymmetric organocatalytic cascade reactions, several efficient methods for the construction of optically pure compounds with quaternary carbon centers have been developed. This focused review highlights the asymmetric synthesis of chiral compounds with quaternary centers through organocatalytic cascade reactions.

引用

页码：580 / 607

页数：28

共 125 条

[31] Tandem [4+2]/[3+2] cycloadditions of nitroalkenes [J].