Strontium-substituted biphasic calcium phosphate microspheres promoted degradation performance and enhanced bone regeneration

被引：30
作者：
Chen, Ying [1 ,2 ,3 ,4 ]
Liu, Zhongning [1 ,2 ,3 ,4 ]
Jiang, Ting [1 ,2 ,3 ,4 ]
Zou, Xinyu [5 ]
Lei, Lei [1 ,2 ,3 ,4 ]
Yan, Wenjuan [6 ]
Yang, Jingwen [1 ,2 ,3 ,4 ]
Li, Bo [5 ]
机构：
[1] Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
[2] Natl Clin Res Ctr Oral Dis, Beijing 100081, Peoples R China
[3] Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
[4] Beijing Key Lab Digital Stomatol, Beijing 100081, Peoples R China
[5] Chongqing Univ Sci & Technol, Chongqing Key Lab Nano Micro Composite Mat & Devi, Chongqing 401331, Peoples R China
[6] Peking Univ, Clin Div 1, Sch & Hosp Stomatol, Beijing, Peoples R China
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2020年 / 108卷 / 04期
基金：
中国国家自然科学基金;
关键词：
biphasic calcium phosphate; bone regeneration; degradation; microspheres; strontium-substituted; BETA-TRICALCIUM PHOSPHATE; OSTEOGENIC DIFFERENTIATION; HYDROXYAPATITE; CERAMICS; OSTEOINDUCTION; PROLIFERATION; OSTEOCLASTS; TISSUE; DOGS;
D O I：
10.1002/jbm.a.36867
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Biphasic calcium phosphate (BCP) ceramics are the subject of much attention for use as bone replacement material. However, it remains a challenge to promote the degradation and osteoinductivity performances of BCP ceramics. In this work, novel BCP ceramic microspheres with good degradation and excellent osteoinductivity were prepared through high-content strontium (Sr) doping. The in vitro results indicated that the Sr10-BCP, Sr40-BCP, and Sr80-BCP microspheres all had their HA crystals partially transformed to the beta tricalcium phosphate phase following high-temperature sintering because of Ca-deficient HA formed by the partial substitution of Ca ions by Sr ions. In addition, the degradation rate was increased with the doping of increasing amounts of Sr. All prepared microspheres enhanced human bone marrow-derived mesenchymal stem cells attachment and proliferation. Specifically, among these modified microspheres, the Sr40-BCP microspheres showed the highest osteogenic potential. Furthermore, Sr40-BCP and HA microspheres were implanted in a calvarial defect model of rat to evaluate the in vivo bone augmentation ability. The results indicated that Sr40-BCP microspheres degraded more completely and significantly promoted new bone regeneration compared with HA microspheres. In conclusion, Sr40-BCP microspheres have excellent potential for degradation and bone regeneration and are promising osteogenic materials.
引用
收藏
页码：895 / 905
页数：11
相关论文
共 34 条
[31]   Strontium Enhances Osteogenic Differentiation of Mesenchymal Stem Cells and In Vivo Bone Formation by Activating Wnt/Catenin Signaling [J].
Yang, Fan ;
Yang, Dazhi ;
Tu, Jie ;
Zheng, Qixin ;
Cai, Lintao ;
Wang, Liping .
STEM CELLS, 2011, 29 (06) :981-991
[32]   A comparison of bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) implanted in muscle and bone of dogs at different time periods [J].
Yuan, H. ;
van Blitterswijk, C. A. ;
de Groot, K. ;
de Bruijn, J. D. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 78A (01) :139-147
[33]   Bone formation induced by calcium phosphate ceramics in soft tissue of dogs:: a comparative study between porous α-TCP and β-TCP [J].
Yuan, HP ;
De Bruijn, JD ;
Li, YB ;
Feng, JQ ;
Yang, ZJ ;
De Groot, K ;
Zhang, XD .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (01) :7-13
[34]   Osteoinductive ceramics as a synthetic alternative to autologous bone grafting [J].
Yuan, Huipin ;
Fernandes, Hugo ;
Habibovic, Pamela ;
de Boer, Jan ;
Barradas, Ana M. C. ;
de Ruiter, Ad ;
Walsh, William R. ;
van Blitterswijk, Clemens A. ;
de Bruijn, Joost D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13614-13619
1234