High-Pressure-Promoted Multicomponent and Metal-Free Synthesis of Polyfunctionalized Biaryls

被引：15

作者：

Minuti, Lucio ^{[1
]}

Piazzolla, Francesca ^{[2
]}

Temperini, Andrea ^{[2
]}

机构：

[1] Univ Perugia, Dipartimento Chim Biol & Biotecnol, Via Elce Sotto 8, I-06123 Perugia, Italy

[2] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, Via Liceo 1, I-06123 Perugia, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 36期

关键词：

Multicomponent reactions; High-pressure chemistry; Acylation; Cycloaddition; Biaryls; DIELS-ALDER APPROACH; PRIVILEGED STRUCTURES; ELLAGIC ACID; DISCOVERY; CATALYST; ACCESS; AMINES; AGENT; METABOLISM; ANALOGS;

D O I：

10.1002/ejoc.201700898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and metal-free synthesis of biaryls and heterobiaryls has been developed through a key three-component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 degrees C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal-uncontamined 1,1-biaryls and heterobiaryls in an energy- and step-economic fashion.

引用

页码：5370 / 5377

页数：8

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