The Abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis

被引：44

作者：

Freundlich, Joel S. ^{[1
]}

Lalgondar, Mallikarjun ^{[1
]}

Wei, Jun-Rong ^{[2
]}

Swanson, Stephanie ^{[1
]}

Sorensen, Erik J. ^{[3
]}

Rubin, Eric J. ^{[2
]}

Sacchettini, James C. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[2] Harvard Univ, Dept Immunol & Infect Dis, Sch Publ Hlth, Boston, MA 02115 USA

[3] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

来源：

TUBERCULOSIS | 2010年 / 90卷 / 05期

关键词：

Mycobacterium tuberculosis; Abyssomicin; p-Aminobenzoate metabolism; MARINE VERRUCOSISPORA STRAIN; ESSENTIAL GENES; PATHWAY; MUTAGENESIS; AB-18-032; TARGET;

D O I：

10.1016/j.tube.2010.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The antimycobacterial efficacy of the abyssomicin C family of natural products, in addition to a key synthetic intermediate, has been investigated given their reported inhibition of Bacillus subtilis p-aminobenzoate biosynthesis. The naturally occurring (-)-abyssomicin C and its atropisomer were found to exhibit low micromolar growth inhibition against the relatively fast-growing and non-virulent Mycobacterium smegmatis and the vaccine strain Mycobacterium bovis BCG, while their antipodes were slightly less active. (-)-Abyssomicin C and its atropisomer were particularly efficacious against Mycobacterium tuberculosis H37Rv, exhibiting MIC values of 3.6 and 7.2 mu M, respectively. More specifically, (-)-abyssomicin C was bactericidal. This complex natural product and its analogs, thus, hold promise as chemical tools in the study of M. tuberculosis metabolism. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：298 / 300

页数：3

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