Synthesis and pharmacological investigation of 3-subsituted-amino-2-methylsulfanyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-ones as analgesic and anti-inflammatory agents

被引：7

作者：

Alagarsamy, V.

Solomon, V. Raja

Deepa, G.

Parthiban, P.

Anjana, G. V.

机构：

[1] Dayananda Sagar Coll Pharm, Med Chem Res Lab, Bangalore 560078, Karnataka, India

[2] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[3] Arulmigu Kalasalingam Coll Pharm, Med Chem Res Lab, Anand, Krishnankovil, India

来源：

ARCHIV DER PHARMAZIE | 2007年 / 340卷 / 07期

关键词：

analgesic; anti-inflammatory activity; thienopyrimidin-4-one;

D O I：

10.1002/ardp.200700017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present work, design, synthesis, and pharmacological evaluation of the analgesic, antiinflammatory, and ulcerogenic-index activities of new 3-subsituted-amino-2-methylsulfanyl5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-dlpyrimidin-4-ones, structurally planed by exploiting a clear concept of bio-isosterism, are reported. All compounds exhibited significant analgesic and anti-inflammatory activity. Compounds Al, A3 showed higher analgesic activity and more potent anti-inflammatory activity than that of the reference compound diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to that of acetylsalicylic acid.

引用

页码：352 / 358

页数：7

共 22 条

[1]

Abdel-Rahman AE, 2003, PHARMAZIE, V58, P372

[2]

Alagarsamy V., 2006, Indian Journal of Pharmaceutical Sciences, V68, P108

[3] Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones [J].