Understanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies

被引：49

作者：

Agus, Allison ^{[1
,2
]}

Massier, Sebastien ^{[1
,2
]}

Darfeuille-Michaud, Arlette ^{[1
,2
,3
]}

Billard, Elisabeth ^{[1
,2
,3
]}

Barnich, Nicolas ^{[1
,2
,3
]}

机构：

[1] Univ DAuvergne, Clermont Univ, CBRV, M2iSH,UMR INSERM 1071, F-63001 Clermont Ferrand, France

[2] INRA, Unite Contrat 2018, F-63001 Clermont Ferrand, France

[3] Inst Univ Technol, F-63172 Aubiere, France

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; INNATE LYMPHOID-CELLS; FECAL MICROBIOTA TRANSPLANTATION; MUCOSA-ASSOCIATED MICROBIOTA; INTESTINAL EPITHELIAL-CELLS; REGULATORY T-CELLS; ULCERATIVE-COLITIS; GUT MICROBIOTA; ILEAL MUCOSA; HIGH PREVALENCE;

D O I：

10.1155/2014/567929

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive Escherichia coli (AIEC) that can increase incidence and severity of gut inflammation in the context of Crohn's disease (CD). This review will report the importance of AIEC as triggers of intestinal inflammation, focusing on their impact on epithelial barrier function and stimulation of mucosal inflammation. Beyond manipulation of immune response, restoration of gut microbiota as a new treatment option for CD patients will be discussed.

引用

页数：16

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