Assessment of aortic stiffness by cardiovascular magnetic resonance following the treatment of severe aortic stenosis by TAVI and surgical AVR

被引：26

作者：

Al Musa, Tarique ^{[1
,2
]}

Uddin, Akhlaque ^{[1
,2
]}

Fairbairn, Timothy A. ^{[1
,2
]}

Dobson, Laura E. ^{[1
,2
]}

Sourbron, Steven P. ^{[3
]}

Steadman, Christopher D. ^{[4
]}

Motwani, Manish ^{[1
,2
]}

Kidambi, Ananth ^{[1
,2
]}

Ripley, David P. ^{[1
,2
]}

Swoboda, Peter P. ^{[1
,2
]}

McDiarmid, Adam K. ^{[1
,2
]}

Erhayiem, Bara ^{[1
,2
]}

Oliver, James J. ^{[5
]}

Blackman, Daniel J. ^{[5
]}

Plein, Sven ^{[1
,2
]}

McCann, Gerald P. ^{[4
]}

Greenwood, John P. ^{[1
,2
]}

机构：

[1] Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Div Cardiovasc & Diabet Res, Leeds Inst Cardiovasc & Metab Med, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Div Med Phys, Leeds Inst Cardiovasc & Metab Med, Leeds LS2 9JT, W Yorkshire, England

[4] Univ Leicester, Glenfield Gen Hosp, Natl Inst Hlth Res, Cardiovasc Biomed Res Unit,Cardiovasc Res Ctr,Dep, Leicester, Leics, England

[5] Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Leeds, W Yorkshire, England

来源：

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE | 2016年 / 18卷

关键词：

Aortic stenosis; Transcatheter aortic valve implantation; Aortic valve replacement; Aortic distensibility; Pulse wave velocity; Cardiovascular magnetic resonance; VASA VASORUM FLOW; VALVE-REPLACEMENT; ARTERIAL COMPLIANCE; ROOT REPLACEMENT; THORACIC AORTA; RISK PATIENTS; DISTENSIBILITY; HYPERTROPHY; MORTALITY;

D O I：

10.1186/s12968-016-0256-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Aortic stiffness is increasingly used as an independent predictor of adverse cardiovascular outcomes. We sought to compare the impact of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) upon aortic vascular function using cardiovascular magnetic resonance (CMR) measurements of aortic distensibility and pulse wave velocity (PWV). Methods and results: A 1.5 T CMR scan was performed pre-operatively and at 6 m post-intervention in 72 patients (32 TAVI, 40 SAVR; age 76 +/- 8 years) with high-risk symptomatic severe aortic stenosis. Distensibility of the ascending and descending thoracic aorta and aortic pulse wave velocity were determined at both time points. TAVI and SAVR patients were comparable for gender, blood pressure and left ventricular ejection fraction. The TAVI group were older (81 +/- 6.3 vs. 72.8 +/- 7.0 years, p < 0.05) with a higher EuroSCORE II (5.7 +/- 5.6 vs. 1.5 +/- 1.0 %, p < 0.05). At 6 m, SAVR was associated with a significant decrease in distensibility of the ascending aorta (1.95 +/- 1.15 vs. 1. 57 +/- 0.68 x 10(-3) mm Hg-1, p = 0.044) and of the descending thoracic aorta (3.05 +/- 1.12 vs. 2.66 +/- 1.00 x 10(-3) mm Hg-1, p = 0.018), with a significant increase in PWV (6.38 +/- 4.47 vs. 11.01 +/- 5.75 ms(-1), p = 0.001). Following TAVI, there was no change in distensibility of the ascending aorta (1.96 +/- 1.51 vs. 1.72 +/- 0.78 x 10(-3) mm Hg-1, p = 0.380), descending thoracic aorta (2.69 +/- 1.79 vs. 2.21 +/- 0.79 x 10(-3) mm Hg-1, p = 0.181) nor in PWV (8.69 +/- 6.76 vs. 10.23 +/- 7.88 ms(-1), p = 0.301) at 6 m. Conclusions: Treatment of symptomatic severe aortic stenosis by SAVR but not TAVI was associated with an increase in aortic stiffness at 6 months. Future work should focus on the prognostic implication of these findings to determine whether improved patient selection and outcomes can be achieved.

引用

页数：10

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