Synthesis of difluoromethyl and deuterium-labeled difluoromethyl thioethers from aliphatic electrophiles

被引:18
作者
Ding, Tianqi [1 ]
Jiang, Lvqi [1 ]
Yi, Wenbin [1 ]
机构
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
ONE-POT THIOETHERIFICATION; ALPHA-FLUORINATED ETHERS; ARYL HALIDES; AMINES; THIOUREA; SULFUR; DIFLUOROCARBENE; DEUTERATION; GENERATION; CHEMISTRY;
D O I
10.1039/c9cc09709k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A one-pot difluoromethylthiolation of alkyl electrophiles with thiourea and diethyl bromodifluoromethylphosphonate is described. The transition-metal-free approach, readily available reagents, and mild conditions provide a practical way for the synthesis of difluoromethyl thioethers. By changing the "H" source to the most commonly used "D" sources CD3OD and D2O, this strategy enables efficient synthesis of SCF2D-substituted molecules in good yields with high levels of D incorporation.
引用
收藏
页码:3995 / 3998
页数:4
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