Role of intra-accumbal orexin receptors in the acquisition of morphine induced conditioned place preference in the rats

被引:26
作者
Alizamini, Mirmohammadali Mirramezani [1 ]
Farzinpour, Zahra [2 ]
Ezzatpanah, Somayeh [1 ]
Haghparast, Abbas [1 ]
机构
[1] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, POB 19615-1178, Tehran, Iran
[2] Univ Sci & Technol China, Key Lab Brain Funct & Dis, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
关键词
Reward; Orexin receptors; Nucleus accumbens; Acquisition; Conditioned place preference; Rat; VENTRAL TEGMENTAL AREA; LATERAL HYPOTHALAMUS; CHEMICAL-STIMULATION; NUCLEUS-ACCUMBENS; REWARD-SEEKING; INVOLVEMENT; EXPRESSION; NEURONS; SYSTEMS; OREXIN/HYPOCRETIN;
D O I
10.1016/j.neulet.2017.09.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Orexin receptor shave essential role in the induction of reward-related behaviors to several drugs of abuse. In the present study, we investigated the effects of bilateral administration of SB334867, as an orexin-1 receptor antagonist, and TCS OX2 29, as an orexin-2 receptor antagonist, into the nucleus accumbens (NAc) on the acquisition of morphine-induced conditioned place preference (CPP) in the rats. Adult male Wistar rats (n = 80; 220-250 g) were entered in a CPP paradigm. Bilateral microinjections of different doses of SB334867 (1, 3, 10 and 30 nM) or TCS OX2 29 (3, 10, 30 and 100 nM) into the NAc (0.5 mu l/side) were done 5 min before subcutaneous injection of morphine (5 mg/kg) during 3-dayconditioning (acquisition) phase. The CPP scores and locomotor activity of animals were recorded by video tracking system and Ethovision software. The results demonstrated that intra-NAc microinjection of 3, 10 and 30 nM solutions of SB334867 markedly decreased the acquisition of morphine-induced CPP in a dose-dependent manner. Intra-accumbal injection of 10, 30 and 100 nM solutions of TCS OX2 29 significantly attenuated the acquisition of morphine CPP as well. In addition, contribution of orexin-1 receptors to development of morphine reward-related behaviors was more than orexin-2 receptors. Our results suggest that both orexin-1 and 2 receptors in the NAc are involved in the development of morphine-induced CPP. It seems that orexin-1 receptors in this region are more effective in development of drug seeking behaviors in the rats.
引用
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页码:1 / 5
页数:5
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