A novel procedure for conversion of epoxides to α-hydroxyphosphonates with a trialkylphosphite mediated by LiClO4

被引：10

作者：

Azizi, N ^{[1
]}

Said, MR ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 43期

关键词：

epoxide; alpha-hydroxypliosphonates; trialkylphosphite; lithium perchlorate;

D O I：

10.1016/j.tetlet.2003.09.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method has been developed for the direct conversion of epoxides to alpha-hydroxyphosphonates by the reaction of a trialkylphosphite with the epoxide in 5 M lithium perchlorate in diethyl ether (LPDE). The reaction is highly regioselective and efficient with excellent yields under mild and neutral conditions. (C) 2003 Published by Elsevier Ltd.

引用

收藏

页码：7933 / 7935

页数：3

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