DLC-1: a Rho GTPase-activating protein and tumour suppressor

被引：165
作者：
Durkin, Marian E.
Yuan, Bao-Zhu
Zhou, Xiaoling
Zimonjic, Drazen B.
Lowy, Douglas R.
Thorgeirsson, Snorri S.
Popescu, Nicholas C.
机构：
[1] NCI, Ctr Canc Res, Expt Carcinogenesis Lab, Bethesda, MD 20892 USA
[2] NIOSH, Ctr Dis Control, Lab Mol Genet Toxicol, Morgantown, WV USA
[3] NIOSH, Ctr Dis Control, Mol Biol Branch, Morgantown, WV USA
[4] NCI, Canc Res Ctr, Cellular Oncol Lab, Bethesda, MD 20892 USA
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2007年 / 11卷 / 05期
关键词：
deleted in liver cancer; GTPase activating protein; tumour suppressor; metastasis suppressor; cytoskeletal organization; tensin; focal adhesion; cancer detection; cancer therapy;
D O I：
10.1111/j.1582-4934.2007.00098.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.
引用
收藏
页码：1185 / 1207
页数：23
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