Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

被引：10

作者：

Feng, Chenchen ^{[1
,2
]}

Lyu, Yinfeng ^{[2
]}

Gong, Lingxiao ^{[1
]}

Wang, Jing ^{[1
]}

机构：

[1] Beijing Technol & Business Univ BTBU, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100000, Peoples R China

[2] Fudan Univ, Huashan Hosp, Dept Urol, Shanghai 200040, Peoples R China

来源：

NUTRIENTS | 2022年 / 14卷 / 11期

基金：

中国国家自然科学基金;

关键词：

natural products; renal cell carcinoma; anti-cancer; ANTI-ANGIOGENESIS; RADICAL NEPHRECTOMY; DOWN-REGULATION; CANCER CELLS; EXTRACT; TUMOR; EXPRESSION; COMBINATION; PROGRESSION; METASTASIS;

D O I：

10.3390/nu14112274

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Renal cell carcinoma (RCC) is a common cancer of the urinary system. The potential therapeutic effects of certain natural products against renal cell carcinoma have been reported both in vivo and in vitro, but no reviews have been published classifying and summarizing the mechanisms of action of various natural products. In this study, we used PubMed and Google Scholar to collect and screen the recent literature on natural products with anti-renal-cancer effects. The main mechanisms of action of these products include the induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis and reduction of drug resistance. In total, we examined more than 30 natural products, which include kahweol acetate, honokiol, englerin A and epigallocatechin-3-gallate, among others, have demonstrated a variety of anti-renal-cancer effects. In conclusion, natural products may have a wider application in kidney cancer than previously believed and are potential candidates for treatment in RCC.

引用

页数：15

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