Stereoselective synthesis of 2,6-dideoxy; 3,6-dideoxy; 2,3,6-trideoxy-inositol 1,4,5-trisphosphate and 6-deoxy-inositol 1,3,4,5-tetrakisphosphate analogues from 6-deoxy-D-inositol precursors

被引：0

作者：

Benício, AAA

Da Silva, AD ^{[1
]}

De Almeida, MV

Da Silva, MM

Gero, SD

机构：

[1] Univ Fed Juiz de Fora, Dept Quim, Inst Ciencias Exatas, BR-36036330 Juiz De Fora, MG, Brazil

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON | 2001年 / 57卷 / 07期

关键词：

inositol 1,4,5-bisphosphate; phosphoinositide cascade; lipophilic substituents;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel 2,6-dideoxy-2,2-difluoro; 2,6-dideoxy-2-fluoro; and 2,3,6-trideoxy-2,3-difluoro-Ins(1,4,5)tris (dibutyl)phosphates and 6-deoxy-D-chiro-inositol 1,3,4,5-tetrakis(dibutyl)phosphate analogues were synthesized in optically pure form. Modification of Ins(1,4,5)P-3 and Ins(1,3,4,5)P-4 analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1161 / 1167

页数：7

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