An efficient and facile one-pot synthesis of propargylamines by three-component coupling of aldehydes, amines, and alkynes via C-H activation catalyzed by NiCl2

被引：140

作者：

Samai, Subhasis ^{[1
]}

Nandi, Ganesh Chandra ^{[1
]}

Singh, M. S. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 42期

关键词：

Three-component A(3)-coupling; C-H bond activation; NiCl2; Propargylamines; Aldehydes; Amines; DIRECT-ADDITION; MULTICOMPONENT REACTIONS; TERMINAL ALKYNES; REUSABLE CATALYST; COPPER; SILVER; COMPLEX; CONDENSATION; ALKYNYLATION; IMINES;

D O I：

10.1016/j.tetlet.2010.08.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

NiCl2 was found to be a highly efficient and effective catalyst for the one-pot three-component (A(3)) coupling of aldehydes, amities, and alkynes to produce propargylamines in nearly quantitative yields. Structurally divergent aldehydes, amines, and alkynes were converted into the corresponding propargylamines. No co-catalyst or activator is needed and water is the only byproduct of this novel protocol. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5555 / 5558

页数：4

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