Adipogenic function of mouse tetranectin and identification of its functional domain

被引：7

作者：

Park, Jihyun ^{[1
]}

Ryu, Young ^{[1
]}

Rahman, Safikur ^{[1
]}

Kim, Jihoe ^{[1
]}

机构：

[1] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 712749, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 519卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Adipocyte differentiation; Tetranectin; Plasminogen; Adipogenic function; PLASMINOGEN KRINGLE 4; BINDING-PROTEIN; GENE; IMMUNOREACTIVITY; EXPRESSION; SEQUENCE; CLONING; SITE;

D O I：

10.1016/j.bbrc.2019.09.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetranectin (TN), a plasminogen (Plg) binding protein, enhances the Plg activator (PA)-catalyzed activation of Plg to plasmin (Pln). Previously, TN was identified as an adipogenic serum protein, which promotes adipocyte differentiation. In the present study, we investigated the adipogenic function of mouse TN using recombinant proteins (rmTNs) in full-length and domain-truncated forms. Adipocyte differentiation in TN-depleted-FBS-media was significantly enhanced by rmTNs supplementation. The adipogenic effect of rmTNs was found to be dependent on the presence of a Plg binding domain, indicating the domain is essential for the adipogenic function of mTN. In addition, these results suggested the involvement of Plg activation, however Plg, PA and Pln appeared to have no direct effect on adipocyte differentiation. This study demonstrates the adipogenic function of mTN, which is dependent on the Plg binding domain as its functional domain. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：645 / 651

页数：7

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