Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

被引：137

作者：

Pei, Lin ^{[1
]}

Li, Shupeng ^{[1
]}

Wang, Min ^{[1
]}

Diwan, Mustansir ^{[1
]}

Anisman, Hymie ^{[2
]}

Fletcher, Paul J. ^{[1
,3
,4
]}

Nobrega, Jose N. ^{[1
,3
,4
]}

Liu, Fang ^{[1
,3
]}

机构：

[1] Ctr Addict & Mental Hlth, Dept Neurosci, Toronto, ON, Canada

[2] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada

来源：

NATURE MEDICINE | 2010年 / 16卷 / 12期

关键词：

REUPTAKE INHIBITORS; SWIMMING TEST; DEPRESSION; SCHIZOPHRENIA; IMMOBILITY; ACTIVATION; PROTEIN; SYSTEM; DRUGS;

D O I：

10.1038/nm.2263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report that coupling between dopamine D1 and D2 receptors was markedly increased in postmortem brain of subjects suffering from major depression. Biochemical analyses revealed that D1 and D2 receptors form heterodimers via a direct protein-protein interaction. Administration of an interfering peptide that disrupts the D1-D2 receptor complex substantially reduced immobility in the forced swim test (FST) without affecting locomotor activity, and decreased escape failures in learned helplessness tests in rats. (C) 2010 Nature America, Inc. All rights reserved.

引用

页码：1393 / 1395

页数：3

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