Three Rwandan Children With Massive Splenomegaly and Epstein-Barr Virus-associated Lymphoproliferative Disorders: Case Presentations and the Literature Review

被引：3

作者：

Friedman-Klabanoff, DeAnna ^{[1
]}

Ball, Allison ^{[2
]}

Rutare, Samuel ^{[3
]}

McCall, Natalie ^{[4
]}

Blackall, Douglas P. ^{[5
,6
]}

机构：

[1] Duke Univ, Dept Pediat, Sch Med, Durham, NC 27706 USA

[2] Dartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA

[3] Kigali Univ Teaching Hosp, Dept Pediat, Kigali, Rwanda

[4] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA

[5] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Boston, MA USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2016年 / 38卷 / 05期

关键词：

Epstein-Barr virus; lymphoproliferative disorder; pancytopenia; splenectomy; splenomegaly; ENDEMIC BURKITT-LYMPHOMA; NONIMMUNOCOMPROMISED HOSTS; MALNUTRITION; INFECTION; MALARIA;

D O I：

10.1097/MPH.0000000000000561

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This report describes 3 Rwandan children with massive splenomegaly and pancytopenia who underwent splenectomy. Each was diagnosed with Epstein-Barr virus-associated lymphoproliferative disorder (EBV LPD) based on lymphocyte morphology, lymphocyte immunophenotype, and the results of EBV in situ hybridization studies. The differential diagnosis of splenomegaly, with a special emphasis on the sub-Saharan African context, is discussed along with EBV and associated disorders. These cases serve as a call to consider EBV LPD in the differential diagnosis of splenomegaly in children in whom common causes have been ruled out.

引用

页码：E158 / E161

页数：4

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