Molecular mechanisms involved in intestinal iron absorption

被引:139
作者
Sharp, Paul
Srai, Sudit Kaila
机构
[1] Kings Coll London, Dept Nutr & Dietet, Div Nutr Sci, London SE1 9NH, England
[2] UCL, Dept Biochem & Mol Biol, London NW3 2PF, England
关键词
haem; non-haem iron; DMT1; IREGI; Dcytb; hephaestin;
D O I
10.3748/wjg.v13.i35.4716
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Iron is an essential trace metal in the human diet due to its obligate role in a number of metabolic processes. In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin). This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation. While many components of the iron transport pathway have been elucidated, a number of key issues still remain to be resolved. Future work in this area will provide a clearer picture regarding the transcellular flux of iron and its regulation by dietary and humoral factors. (C) 2007 WJG. All rights reserved.
引用
收藏
页码:4716 / 4724
页数:9
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