Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

被引：132

作者：

Grandjean, Joanes ^{[1
]}

Canella, Carola ^{[2
,3
]}

Anckaerts, Cynthia ^{[4
]}

Ayranci, Gulebru ^{[5
]}

Bougacha, Salma ^{[6
,7
]}

Bienert, Thomas ^{[8
,9
,10
,32
]}

Buehlmann, David ^{[11
]}

Coletta, Ludovico ^{[2
,3
]}

Gallino, Daniel ^{[5
]}

Gass, Natalia ^{[12
,13
]}

Garin, Clement M. ^{[6
,7
]}

Nadkarni, Nachiket Abhay ^{[6
,7
]}

Huebner, Neele S. ^{[8
,9
,10
,32
]}

Karatas, Meltem ^{[8
,9
,14
]}

Komaki, Yuji ^{[15
,16
]}

Kreitz, Silke ^{[17
]}

Mandino, Francesca ^{[1
,18
]}

Mechling, Anna E. ^{[8
,9
,10
,32
]}

Sato, Chika ^{[19
]}

Sauer, Katja ^{[17
]}

Shah, Disha ^{[4
,20
]}

Strobelt, Sandra ^{[17
]}

Takata, Norio ^{[15
]}

Wank, Isabel ^{[17
]}

Wu, Tong ^{[21
,22
,23
,34
,35
]}

Yahata, Noriaki ^{[19
]}

Yeow, Ling Yun ^{[1
]}

Yee, Yohan ^{[24
,25
,29
]}

Aoki, Ichio ^{[19
]}

Chakravarty, M. Mallar ^{[5
,30
,31
]}

Chang, Wei-Tang ^{[1
]}

Dhenain, Marc ^{[6
,7
]}

von Elverfeldt, Dominik ^{[8
,9
,10
,32
]}

Harsan, Laura-Adela ^{[14
]}

Hess, Andreas ^{[17
]}

Jiang, Tianzi ^{[21
,26
,27
]}

Keliris, Georgios A. ^{[4
]}

Lerch, Jason P. ^{[24
,25
,29
,33
]}

Meyer-Lindenberg, Andreas ^{[28
]}

Okano, Hideyuki ^{[16
]}

Rudin, Markus ^{[11
,36
,37
,38
]}

Sartorius, Alexander ^{[12
,13
]}

Van der Linden, Annemie ^{[4
]}

Verhoye, Marleen ^{[4
]}

Weber-Fahr, Wolfgang ^{[12
,13
]}

Wenderoth, Nicole ^{[38
,39
]}

Zerbi, Valerio ^{[38
,39
]}

Gozzi, Alessandro ^{[2
]}

机构：

[1] Agcy Sci Technol & Res, Singapore Bioimaging Consortium, 11 Biopolis Way, Singapore 138667, Singapore

[2] Ctr Neurosci & Cognit Syst UNITN, Ist Italian Tecnol, Funct Neuroimaging Lab, I-38068 Rovereto, Italy

[3] Univ Trento, Ctr Mind Brain Sci, CIMeC, I-38068 Rovereto, Italy

[4] Univ Antwerp, Bioimaging Lab, CDE, Univ Pl 1, B-2610 Antwerp, Belgium

[5] McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada

[6] Inst Francois Jacob, MIRCen, DRF, Commissariat & Energie Atom & Energies Alternativ, Fontenay Aux Roses, France

[7] Univ Paris Sud, Univ Paris Saclay UMR 9199, CNRS, Neurodegenerat Dis Lab, Fontenay Aux Roses, France

[8] Univ Zurich, Inst Biomed Engn, Wolfgang Pauli Str 27, CH-8093 Zurich, Switzerland

[9] Swiss Fed Inst Technol, Wolfgang Pauli Str 27, CH-8093 Zurich, Switzerland

[10] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Neuroimaging, Mannheim, Germany

[11] Univ Freiburg, Fac Med, Med Ctr, Dept Radiol Med Phys, Killianstr 5a, D-79106 Freiburg, Germany

[12] Univ Strasbourg, Dept Biophys & Nucl Med, Engn Sci Comp Sci & Imaging Lab ICube, F-67000 Strasbourg, France

[13] Univ Hosp Strasbourg, F-67000 Strasbourg, France

[14] CIEA, 3-25-12 Tonomachi, Kawasaki, Kanagawa 2100821, Japan

[15] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[16] Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Expt & Clin Pharmacol & Toxicol, Fahrstr 17, D-91054 Erlangen, Germany

[17] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[18] Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Dept Mol Imaging & Theranost, Funct & Mol Imaging Team,Inage Ku, Anagawa 4-9-1, Chiba, Chiba 2638555, Japan

[19] Katholieke Univ Leuven, Lab Res Neurodegenerat Dis, VIB Ctr Brain & Dis Res, O&N4 Herestr 49 Box 602, B-3000 Leuven, Belgium

[20] Keio Univ, Dept Neuropsychiat, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[21] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

[22] UCL, Ctr Med Image Comp, Dept Comp Sci, London, England

[23] UCL, Max Planck Univ Coll London Ctr Computat Psychiat, London, England

[24] Univ Toronto, Hosp Sick Children, Toronto, ON, Canada

[25] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[26] Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China

[27] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China

[28] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Heidelberg, Germany

[29] RIKEN, Brain Sci Inst, Lab Marmoset Neural Architecture, Wako, Saitama 3510198, Japan

[30] Univ Zurich, Dept Hlth Sci & Technol, Neural Control Movement Lab, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[31] Univ Zurich, Inst Pharmacol & Toxicol, Winterthurerstr 190, CH-8057 Zurich, Switzerland

[32] Univ Freiburg, BrainLinks BrainTools Cluster Excellence, Georges Kohler Allee 80, D-79110 Freiburg, Germany

[33] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Oxford OX3 9DU, England

[34] Imperial Coll London, Dept Med, Div Brain Sci, Computat Cognit & Clin Imaging Lab, London W12 0NN, England

[35] Imperial Coll London, UK DRI Ctr Care Res & Technol, London W12 0NN, England

[36] Swiss Fed Inst Technol, Neurosci Ctr Zurich, Zurich, Switzerland

[37] Univ Zurich, Zurich, Switzerland

[38] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[39] McGill Univ, Dept Biol & Biomed Engn, Montreal, PQ, Canada

来源：

NEUROIMAGE | 2020年 / 205卷

基金：

日本科学技术振兴机构; 欧洲研究理事会;

关键词：

Functional connectivity; Default-mode network; ICA; Seed-based; Connectome; DEFAULT-MODE NETWORK; CONNECTIVITY NETWORKS; ANESTHESIA PROTOCOLS; MOTOR CORTEX; MICE; MRI; GENE; MICRODELETION; FLUCTUATIONS; CONNECTOMICS;

D O I：

10.1016/j.neuroimage.2019.116278

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and to investigate the determinants of altered network signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison of 17 mouse rsfMRI datasets via a common image processing and analysis pipeline. Despite prominent cross-laboratory differences in equipment and imaging procedures, we report the reproducible identification of several large-scale resting-state networks (RSN), including a mouse default-mode network, in the majority of datasets. A combination of factors was associated with enhanced reproducibility in functional connectivity parameter estimation, including animal handling procedures and equipment performance. RSN spatial specificity was enhanced in datasets acquired at higher field strength, with cryoprobes, in ventilated animals, and under medetomidine-isoflurane combination sedation. Our work describes a set of representative RSNs in the mouse brain and highlights key experimental parameters that can critically guide the design and analysis of future rodent rsfMRI investigations.

引用

页数：11

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