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Pericardial Adipose Tissue, Atherosclerosis, and Cardiovascular Disease Risk Factors The Jackson Heart Study
被引:98
作者:
Liu, Jiankang
[1
]
Fox, Caroline S.
[2
,3
,4
]
Hickson, DeMarc
[1
]
Sarpong, Daniel
[1
]
Ekunwe, Lynette
[1
]
May, Warren D.
[5
]
Hundley, Gregory W.
[6
]
Carr, J. Jeffery
[6
]
Taylor, Herman A.
[1
]
机构:
[1] Jackson State Univ, Univ Mississippi, Med Ctr, Jackson Heart Study, Jackson, MS 39217 USA
[2] NHLBI, Framingham Heart Study, Boston, MA USA
[3] Brigham & Womens Hosp, Dept Med, Div Endocrinol Metab & Diabet, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA USA
[5] Jackson State Univ, Univ Mississippi, Med Ctr, Dept Prevent Med, Jackson, MS USA
[6] Wake Forest Univ, Bowman Gray Sch Med, Dept Cardiol & Radiol, Winston Salem, NC USA
关键词:
METABOLIC SYNDROME;
EPICARDIAL FAT;
ASSOCIATION;
D O I:
10.2337/dc10-0245
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
OBJECTIVE - Pericardial adipose tissue (PAT), a regional fat depot that surrounds the heart, is associated with an unfavorable cardiometabolic risk factor profile. The associations among PAT, cardiometabolic risk factors, and coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) in African American populations have not been explored. RESEARCH DESIGN AND METHODS - A total of 1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years) drawn from the Jackson Heart Study (JHS) underwent multidetector computed tomography assessment of abdominal visceral adipose tissue (VAT) and PAT between 2007 and 2009. Cardiometabolic risk factors, CAC, and AAC were examined in relation to increments of PAT and VAT. RESULTS - PAT was significantly correlated with BMI, waist circumference, and VAT (r = 0.35, 0.46, and 0.69; all P < 0.0001). PAT (per 1-SD increase) was associated with elevated levels of systolic blood pressure (P < 0.04), fasting glucose, triglycerides, and C-reactive protein and lower levels of HDL (all P values<0.0001). PAT was also associated with metabolic syndrome (odds ratio [OR] 1.89; P < 0.0001), hypertension (1.48; P < 0.0006), and diabetes (1.40; P < 0.04); all associations were diminished after further adjustment for VAT (most P > 0.05). However, the association of PAT with CAC but not with AAC remained significant (OR 1.34 [95% Cl 1.10-1.64]; P < 0.004) after multivariable and VAT adjustment. CONCLUSIONS - PAT is significantly correlated with most cardiometabolic risk factors and CAC in the JHS cohort. The results suggest that PAT is an important VAT depot that may exert a local effect on the coronary vasculature.
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页码:1635 / 1639
页数:5
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