A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals

被引：9

作者：

Abbasnezhad, Abbasali ^{[1
]}

Salami, Fatemeh ^{[2
]}

Mohebbati, Reza ^{[1
,3
]}

机构：

[1] Gonabad Univ Med Sci, Dept Physiol, Fac Med, Gonabad, Iran

[2] Mashhad Univ Med Sci, Dept Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

来源：

ANIMAL MODELS AND EXPERIMENTAL MEDICINE | 2022年 / 5卷 / 05期

关键词：

animal; drug toxicity; drug-induced abnormality; liver dysfunction; renal injury; CADMIUM-INDUCED NEPHROTOXICITY; CISPLATIN-INDUCED APOPTOSIS; INDUCED OXIDATIVE STRESS; RENAL TUBULAR CELLS; VALPROIC ACID; LIPID-PEROXIDATION; CYCLOSPORINE-A; MITOCHONDRIAL DYSFUNCTION; INDUCED HEPATOTOXICITY; OXIDANT STRESS;

D O I：

10.1002/ame2.12230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Therapeutic experiments are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals. The current narrative review used databases such as Medline, Web of Science, Scopus, and Embase and appropriate keywords until June 2021. Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin, acetaminophen, doxorubicin, some anticancer drugs, and other materials through various signaling pathways are investigated. To understand the models of renal or hepatotoxicity in laboratory animals, we have provided a list of toxic agents and their toxicity procedures in this review.

引用

页码：436 / 444

页数：9

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