Host-Guest System of Nimbin and β-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization

被引：41

作者：

Yang, Li-Juan ^{[1
]}

Yang, Bo ^{[1
]}

Chen, Wen ^{[1
]}

Huang, Rong ^{[1
]}

Yan, Sheng-Jiao ^{[1
]}

Lin, Jun ^{[1
,2
]}

机构：

[1] Yunnan Univ, Key Lab Med Chem Nat Resources, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2010年 / 58卷 / 15期

关键词：

Nimbin; beta-cyclodextrin; inclusion complex; binding ability; characterization; inclusion mode; AZADIRACHTA-INDICA; BRIDGED BIS(BETA-CYCLODEXTRIN)S; HERBICIDE NORFLURAZON; ANALYTICAL-CHEMISTRY; INSECT ANTIFEEDANTS; COMPLEXATION; NEEM; BEHAVIOR; BINDING; ADSORPTION;

D O I：

10.1021/jf101079e

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The inclusion complexation behavior, characterization, and binding ability of nimbin with beta-cyclodextrin (beta-CD) and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, H-1 and 2D NMR, and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of nimbin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the nimbin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.

引用

页码：8545 / 8552

页数：8

共 49 条

[21] Determination of enantiomers of synthetic pyrethroids in water by solid phase microextraction - Enantioselective gas chromatography [J].

Liu, WP ;

Gan, JJ .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (04) :736-741

[22] Inclusion complexes of azadirachtin with native and methylated cyclodextrins: solubilization and binding ability [J].

Liu, Y ;

Chen, GS ;

Chen, Y ;

Lin, J .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (12) :4037-4042

[23] Novel o-phenylenediseleno bridged bis(β-cyclodextrin)s complexes with platinum(IV) and palladium(II) ions [J].

Liu, Y ;

Li, B ;

Wada, T ;

Inoue, Y .

SUPRAMOLECULAR CHEMISTRY, 1999, 10 (04) :279-285

[24] Cooperative binding and multiple recognition by bridged bis(β-cyclodextrin)s with functional linkers [J].

Liu, Yu ;

Chen, Yong .

ACCOUNTS OF CHEMICAL RESEARCH, 2006, 39 (10) :681-691

[25] Cyclodextrins in ophthalmic drug delivery [J].

Loftssona, T ;

Järvinen, T .

ADVANCED DRUG DELIVERY REVIEWS, 1999, 36 (01) :59-79

[26]

Mellet CO, 2002, CHEM-EUR J, V8, P1982, DOI 10.1002/1521-3765(20020503)8:9<1982::AID-CHEM1982>3.0.CO

[27]

2-5

[28] Inclusion complexes of tretinoin with cyclodextrins [J].

Montassier, P ;

Duchene, D ;

Poelman, MC .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (02) :199-209

[29] Modeling the interactions of herbal drugs to β-ketoacyl ACP synthase of Mycobacterium tuberculosis H37Rv [J].

Ramesh, K. V. ;

Purohit, Mitali ;

Mekhala, K. ;

Krishnan, Mrinalini ;

Wagle, Kaushiki ;

Deshmukh, Sudha .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2008, 25 (05) :481-493

[30]

RAO S, Patent No. 0054596

← 1 2 3 4 5 →