Host-Guest System of Nimbin and β-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization

被引:41
作者
Yang, Li-Juan [1 ]
Yang, Bo [1 ]
Chen, Wen [1 ]
Huang, Rong [1 ]
Yan, Sheng-Jiao [1 ]
Lin, Jun [1 ,2 ]
机构
[1] Yunnan Univ, Key Lab Med Chem Nat Resources, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
关键词
Nimbin; beta-cyclodextrin; inclusion complex; binding ability; characterization; inclusion mode; AZADIRACHTA-INDICA; BRIDGED BIS(BETA-CYCLODEXTRIN)S; HERBICIDE NORFLURAZON; ANALYTICAL-CHEMISTRY; INSECT ANTIFEEDANTS; COMPLEXATION; NEEM; BEHAVIOR; BINDING; ADSORPTION;
D O I
10.1021/jf101079e
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
The inclusion complexation behavior, characterization, and binding ability of nimbin with beta-cyclodextrin (beta-CD) and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, H-1 and 2D NMR, and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of nimbin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the nimbin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.
引用
收藏
页码:8545 / 8552
页数:8
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