Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer

被引：19

作者：

Fleming, Cathy ^{[1
,2
]}

Cagney, Daniel N. ^{[3
]}

O'Keeffe, Serena ^{[1
,2
]}

Brennan, Sinead M. ^{[3
]}

Armstrong, John G. ^{[3
]}

McClean, Brendan ^{[1
]}

机构：

[1] St Lukes Hosp, St Lukes Radiat Oncol Network, Dept Phys, Dublin, Ireland

[2] Univ Coll Dublin, UCD Sch Phys, Dublin, Ireland

[3] SL Lukes Hosp, Dept Radiat Oncol, SL Lukes Radiat Oncol Network, Dublin, Ireland

来源：

RADIOTHERAPY AND ONCOLOGY | 2016年 / 119卷 / 03期

关键词：

NSCLC; DVCs; Dose-volume constraints; Toxicity; Hypofractionated; CONFORMAL RADIATION-THERAPY; LOCAL TUMOR-CONTROL; ONCOLOGY-GROUP; PHASE-I; CONCURRENT CHEMORADIOTHERAPY; CHEMORADIATION THERAPY; STEREOTACTIC BODY; RADIOTHERAPY; TOXICITY; ESCALATION;

D O I：

10.1016/j.radonc.2016.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose-volume-constraints (DVCs) published in the literature refer to conventional 2 Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose-volume constraint data discussed and summarised for moderately hypofractionated NSCLC regimes. The OARs examined include lung, brachial plexus, heart, oesophagus, airway and spinal cord. Where available the toxicity rates are also reported with all data summarised tabulated to aid its use in the clinic. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：423 / 431

页数：9

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