An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

被引：151

作者：

Sun, Wangsheng ^{[1
]}

Zhu, Gongming ^{[1
]}

Wu, Chongyang ^{[1
]}

Hong, Liang ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Lanzhou Univ, Inst Biochem & Mol Biol, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov,Sch Li, Lanzhou 730000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 22期

关键词：

cascade reactions; methyleneindolinone; organocatalysis; spiro compounds; squaramides; CATALYTIC ASYMMETRIC-SYNTHESIS; MICHAEL-ALKYLATION REACTIONS; STRUCTURE-BASED DESIGN; ONE-POT SYNTHESIS; SPIROCYCLIC OXINDOLES; DIELS-ALDER; MULTIPLE STEREOCENTERS; CHIRAL SQUARAMIDES; NATURAL-PRODUCTS; DOMINO REACTIONS;

D O I：

10.1002/chem.201200478

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rapid and efficient organocatalytic cascade sequence for the direct construction of spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the presence of a base. This process constitutes a powerful approach to the preparation of biologically important bispirooxindoles in high enantioselectivities (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6737 / 6741

页数：5

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