Progresses in Total Synthesis of Englerin A and Biological Evaluations of Its Analogues

被引：14

作者：

Lu, Yunyu ^{[1
,2
]}

Yao, Hequan ^{[1
]}

Sun, Bingfeng ^{[2
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

englerin A; total synthesis; biological evaluation; progress; GUAIANE SESQUITERPENE; NATURAL-PRODUCTS; CARBONYL-YLIDE; CYCLOADDITION; (-)-ENGLERIN; DRUGS; LEADS;

D O I：

10.6023/cjoc1110141

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Englerin A is an oxo-bridged guaiane-type sesquiterpenoid isolated from Phyllanthus engleri, and displays potent and highly selective inhibitory activities against renal cancer cell lines. In this review, the recent progresses since its disclosure in the total synthesis of englerin A and biological evaluations of its analogues are summarized, with an emphasis on the strategies of the synthetic routes, particularly in regards to the construction of oxatricyclic ring system.

引用

页码：1 / 12

页数：12

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