Advanced Applications of Raman Imaging for Deeper Understanding and Better Quality Control of Formulations

被引：11

作者：

Moriyama, Kei ^{[1
]}

机构：

[1] Shujitsu Univ, Sch Pharm, Okayama, Japan

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 32期

关键词：

Raman spectroscopy; Raman imaging; formulation; manufacturing; active pharmaceutical ingredient; excipient; particle size; tablet; SOLID DOSAGE FORMS; PHARMACEUTICAL TABLETS; VIBRATIONAL SPECTROSCOPY; INFRARED-SPECTROSCOPY; HYPERSPECTRAL IMAGES; DRUG DISTRIBUTION; PARTICLE-SIZE; DISSOLUTION; MICROSCOPY; CHEMOMETRICS;

D O I：

10.2174/1381612822666160726093637

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The importance of using the Raman imaging technique is increasing in pharmaceutical sciences, particularly in the quality control of active pharmaceutical ingredients, formulation design, and manufacturing development. Formulation design based on Raman imaging data is important for achieving quality by design. Recently, several novel Raman imaging measurement and analytical techniques have been reported. It is undoubtedly essential for pharmaceutical researchers and manufacturing engineers to use modern Raman imaging technology to produce the best quality pharmaceutical products. This short review seeks to inform researchers and engineers about recent developments in Raman imaging techniques applicable to formulation design and manufacturing.

引用

页码：4912 / 4916

页数：5

共 69 条

[1]

[Anonymous], 2004, PAT FRAM INN PHARM

[2]

[Anonymous], 2009, ICH HARMON TRIPART G

[3]

[Anonymous], RAM IM DAT FORM

[4] An iterative approach for compound detection in an unknown pharmaceutical drug product: Application on Raman microscopy [J].