Current progress in the development of RNAi-based therapeutics for HIV-1

被引：35

作者：

Zhou, J. ^{[1
]}

Rossi, J. J. ^{[1
]}

机构：

[1] Beckman Res Inst City Hope, Dept Mol & Cellular Biol, Duarte, CA 91010 USA

来源：

GENE THERAPY | 2011年 / 18卷 / 12期

基金：

美国国家卫生研究院;

关键词：

RNAi; siRNA; HIV-1; delivery; DOUBLE-STRANDED-RNA; GENE-THERAPY; INTERFERENCE; DELIVERY; CD4; INFECTION; CELLS; INHIBITION; EXPRESSION; STRATEGIES;

D O I：

10.1038/gt.2011.149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Highly active antiretroviral therapy (HAART) treatment for HIV has changed the course of AIDS in societies in which the drugs are readily available. Despite the great success of HAART, drug resistance and toxicity issues still remain a concern for some individuals. Thus, a number of investigators have been exploring other approaches for inhibiting HIV-1 replication. One of the most potent of these is the use of RNA interference (RNAi). This review will focus solely on the use of RNAi for the treatment of HIV-1 infection, including the problems, progress and future prospects. Gene Therapy (2011) 18, 1134-1138; doi:10.1038/gt.2011.149; published online 29 September 2011

引用

页码：1134 / 1138

页数：5

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