A highly efficient TBAF-promoted intramolecular cyclization of gem-dibromoolefins for the synthesis of 2-bromobenzofurans(thiophenes)

被引：46

作者：

Chen, Wei ^{[1
]}

Zhang, Yicheng ^{[1
]}

Zhang, Lei ^{[1
]}

Wang, Min ^{[1
]}

Wang, Lei ^{[1
,2
]}

机构：

[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 37期

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; TANDEM; 1,1-DIBROMO-1-ALKENES; DERIVATIVES; COUPLINGS; ARYLATION; ALKYNES; INDOLE;

D O I：

10.1039/c1cc13967c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient tetra-(n-butyl) ammonium fluoride (TBAF)-promoted intramolecular cyclization of gem-dibromoolefins has been developed for the synthesis of 2-bromobenzofused heterocycles. The reaction provides a convenient approach to 2-bromobenzofurans(thiophenes) from the corresponding readily available gem-dibromovinyl substrates without a metal.

引用

页码：10476 / 10478

页数：3

共 35 条

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