Plant Science and Human Nutrition: Challenges in Assessing Health-Promoting Properties of Phytochemicals

被引：74
作者：
Traka, Maria H. [1 ]
Mithen, Richard F. [1 ]
机构：
[1] Inst Food Res, Norwich NR4 7UA, Norfolk, England
来源：
PLANT CELL | 2011年 / 23卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
CELL-LINE CACO-2; CRUCIFEROUS VEGETABLE CONSUMPTION; RICH BROCCOLI SPROUTS; DIET-INDUCED OBESITY; LUNG-CANCER RISK; BETA-CAROTENE; PROSTATE-CANCER; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; COLORECTAL-CANCER;
D O I：
10.1105/tpc.111.087916
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The rise in noncommunicable chronic diseases associated with changing diet and lifestyles throughout the world is a major challenge for society. It is possible that certain dietary components within plants have roles both in reducing the incidence and progression of these diseases. We critically review the types of evidence used to support the health promoting activities of certain phytochemicals and plant-based foods and summarize the major contributions but also the limitations of epidemiological and observational studies and research with the use of cell and animal models. We stress the need for human intervention studies to provide high-quality evidence for health benefits of dietary components derived from plants.
引用
收藏
页码：2483 / 2497
页数：15
相关论文
共 158 条
[1]   SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation [J].
Ahuja, D ;
Sáenz-Robles, MT ;
Pipas, JM .
ONCOGENE, 2005, 24 (52) :7729-7745
[2]   Grape Seed Proanthocyanidins Inhibit the Growth of Human Non-Small Cell Lung Cancer Xenografts by Targeting Insulin-Like Growth Factor Binding Protein-3, Tumor Cell Proliferation, and Angiogenic Factors (Publication with Expression of Concern. See vol. 24, pg. 6101, 2018) [J].
Akhtar, Suhail ;
Meeran, Syed M. ;
Katiyar, Nandan ;
Katiyar, Santosh K. .
CLINICAL CANCER RESEARCH, 2009, 15 (03) :821-831
[3]   Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry [J].
Al Janobi, Ahmed A. ;
Mithen, Richard F. ;
Gasper, Amy V. ;
Shaw, P. Nicholas ;
Middleton, Richard J. ;
Ortori, Catharine A. ;
Barrett, David A. .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2006, 844 (02) :223-234
[4]   alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Effects of base-line characteristics and study compliance [J].
Albanes, D ;
Heinonen, OP ;
Taylor, PR ;
Virtamo, J ;
Edwards, BK ;
Rautalahti, M ;
Hartman, AM ;
Palmgren, J ;
Freedman, LS ;
Haapakoski, J ;
Barrett, MJ ;
Pietinen, P ;
Malila, N ;
Tala, E ;
Liippo, K ;
Salomaa, ER ;
Tangrea, JA ;
Teppo, L ;
Askin, FB ;
Taskinen, E ;
Erozan, Y ;
Greenwald, P ;
Huttunen, JK .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (21) :1560-1570
[5]  
[Anonymous], 1994, Ann Epidemiol, V4, P1
[6]   Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes [J].
Astley, SB ;
Elliott, RM ;
Archer, DB ;
Southon, S .
BRITISH JOURNAL OF NUTRITION, 2004, 91 (01) :63-72
[7]  
Aviram M, 2000, AM J CLIN NUTR, V71, P1062
[8]   The effect of gold kiwifruit consumed with an iron fortified breakfast cereal meal on iron status in women with low iron stores: A 16 week randomised controlled intervention study [J].
Beck, Kathryn ;
Conlon, Cathryn ;
Kruger, Rozanne ;
Coad, Jane ;
Stonehouse, Welma .
BMC PUBLIC HEALTH, 2010, 10
[9]   Serum levels of folate, lycopene, β-carotene, retinol and vitamin E and prostate cancer risk [J].
Beilby, J. ;
Ambrosini, G. L. ;
Rossi, E. ;
de Klerk, N. H. ;
Musk, A. W. .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2010, 64 (10) :1235-1238
[10]   NURSES HEALTH STUDY [J].
BELANGER, CF ;
HENNEKENS, CH ;
ROSNER, B ;
SPEIZER, FE .
AMERICAN JOURNAL OF NURSING, 1978, 78 (06) :1039-1040
12345678910