Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

被引：362

作者：

Simpson, Cory L. ^{[1
]}

Patel, Dipal M. ^{[1
]}

Green, Kathleen J. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 09期

基金：

美国国家卫生研究院;

关键词：

CELL-CELL ADHESION; SERUM RESPONSE FACTOR; STRATIFIED SQUAMOUS EPITHELIA; CYTOSKELETAL LINKER PROTEIN; OF-FUNCTION VARIANTS; HAIR-FOLLICLE; CORNIFIED ENVELOPE; STRATUM-CORNEUM; TERMINAL DIFFERENTIATION; DESMOSOMAL CADHERINS;

D O I：

10.1038/nrm3175

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the cornified layers, they completely reorganize their adhesive junctions and cytoskeleton. These architectural components are more than just rivets and scaffolds-they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation.

引用

页码：565 / 580

页数：16

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