Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study

被引：13

作者：

Lee, Hyun Ji ^{[2
]}

Do Han, Kyung ^{[3
]}

Park, Hae Eun ^{[2
]}

Han, Ju Hee ^{[2
]}

Bang, Chul Hwan ^{[2
]}

Park, Young Min ^{[1
]}

Lee, Ji Hyun ^{[2
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Dermatol, Seoul St Marys Hosp, Seoul, South Korea

[2] Catholic Univ Korea, Coll Med, Dept Dermatol, Yeouido St Marys Hosp, Seoul, South Korea

[3] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

PREVALENCE; ASSOCIATION; INFLAMMATION; DISEASE; EPIDEMIOLOGY; MANAGEMENT; DISTINCT; OBESITY;

D O I：

10.1038/s41598-021-03174-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Metabolic syndrome (MetS) is associated with psoriasis, but it remains unclear whether risk of psoriasis remains in patients whose MetS diagnosis changes. To assess the relationship between risk of psoriasis and changes in MetS components. We obtained data from the National Health Insurance Service of Korea and divided the participants into four groups: individuals without MetS (control); individuals with MetS in 2009, but without MetS in 2012 (pre-MetS); individuals without MetS in 2009, but with newly diagnosed MetS in 2012 (post-MetS); and individuals with MetS during the 2009-2012, period (continuous-MetS). We calculated the risk of psoriasis for each group. Risk of psoriasis was similar in the control and pre-MetS groups but was significantly higher in the post-MetS group (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.04-1.12) and in the continuous-MetS group (HR, 1.11; 95% CI, 1.07-1.15) than in the control group. Among MetS components, waist circumference showed the strongest association with psoriasis, followed by high-density lipoprotein and triglyceride levels. Risk of psoriasis was higher in patients with continuous- or post-MetS than in those with pre-MetS (regardless of prior MetS status).

引用

页数：7

共 39 条

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