Phytochemical screening, butyrylcholinesterase inhibitory activity and anti-inflammatory effect of some Tunisian medicinal plants

被引：0
作者：
Edziri, H. [1 ]
Marzouk, B. [1 ]
Mabrouk, H. [2 ]
Garreb, M. [1 ]
Douki, W. [2 ]
Mahjoub, A. [1 ]
Verschaeve, L. [3 ,4 ]
Najjar, F. [2 ]
Mastouri, M. [5 ]
机构：
[1] Fac Pharm, Lab Transmissible Dis & Biol Act Subst, Monastir 5000, Tunisia
[2] CHU Fattouma Bouguiba, Lab Biochim, Monastir 5000, Tunisia
[3] Sci Inst Publ Hlth, Unit Toxicol, B-1050 Brussels, Belgium
[4] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
[5] CHU Fattouma Bouguiba, Lab Microbiol, Monastir 5000, Tunisia
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2018年 / 114卷
关键词：
Marrubium alysson; Peganum harmala; Retama raetam; Butyrylcholinesterase inhibitory activity; Anti-inflammatory activity; Methanol extract; CHOLINESTERASE-INHIBITORS; ALZHEIMERS-DISEASE; LEONOTIS-LEONURUS; MARRUBIUM-ALYSSON; IN-VITRO; ACETYLCHOLINESTERASE; ANTIOXIDANT; GLYCOSIDES; DISCOVERY; COGNITION;
D O I：
10.1016/j.sajb.2017.10.019
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In the present study, we have tested the butyrylcholinesterase (BChE) inhibitory activity of the petroleum ether, ethyl acetate and methanol aerial extracts of Marrubium alysson, Peganum harmala and Retama raetam at 10 and 1000 mu g/mL. The anti-inflammatory activity was determined by the carrageenan-induced paw edema assay in rats. Total flavonoids and phenols and total pigment contents were also investigated. The highest flavonoid contents were found in the methanolic extracts of P. harmala and the highest phenol content in the methanolic extract of R. raetama. The highest concentration of chlorophyll a and b and carotenoids were found in the leaves of P. harmala. The methanol extract of Marrubium alysson showed the best inhibitory activity against BChE (72.5 +/- 2.07%) whereas the methanol extract of Peganum harmala had a moderate inhibitory effect (50.53 +/- 1.98%) at the same concentration of 1 mg/ml. Methanol extracts of M. alysson and P. harmala had the highest anti-inflammatory activity. (c) 2017 SAAB. Published by Elsevier B.V. All rights reserved.
引用
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页码：84 / 88
页数：5
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