Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms

被引：138
作者：
Mahmoud, Rand [1 ]
Wainwright, Steven R. [1 ]
Galea, Liisa A. M. [2 ,3 ]
机构：
[1] Univ British Columbia, Grad Program Neurosci, Vancouver, BC, Canada
[2] Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada
[3] Univ British Columbia, Ctr Brain Hlth, Vancouver, BC, Canada
来源：
FRONTIERS IN NEUROENDOCRINOLOGY | 2016年 / 41卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Estradiol; Estrone; Parity; Testosterone; Androgens; Estrogens; Progesterone; Hippocampus; Neurogenesis; Depression; Stress; Learning and memory; Dementia; Sex differences; ESTROGEN-RECEPTOR-ALPHA; NEUROTROPHIC FACTOR BDNF; TESTOSTERONE REPLACEMENT THERAPY; MESSENGER-RIBONUCLEIC-ACID; MAJOR DEPRESSIVE DISORDER; SPATIAL WORKING-MEMORY; CELL-ADHESION MOLECULE; FORCED SWIM TEST; DENTATE GYRUS; LONG-TERM;
D O I：
10.1016/j.yfrne.2016.03.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurogenesis within the adult hippocampus is modulated by endogenous and exogenous factors. Here, we review the role of sex hormones in the regulation of adult hippocampal neurogenesis in males and females. The review is framed around the potential functional implications of sex hormone regulation of adult hippocampal neurogenesis, with a focus on cognitive function and mood regulation, which may be related to sex differences in incidence and severity of dementia and depression. We present findings from preclinical studies of endogenous fluctuations in sex hormones relating to reproductive function and ageing, and from studies of exogenous hormone manipulations. In addition, we discuss the modulating roles of sex, age, and reproductive history on the relationship between sex hormones and neurogenesis. Because sex hormones have diverse targets in the central nervous system, we overview potential mechanisms through which sex hormones may influence hippocampal neurogenesis. Lastly, we advocate for a more systematic consideration of sex and sex hormones in studying the functional implications of adult hippocampal neurogenesis. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：129 / 152
页数：24
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