Metacaspases

被引：284

作者：

Tsiatsiani, L. ^{[2
,3
,4
,5
]}

Van Breusegem, F. ^{[2
,3
]}

Gallois, P. ^{[6
]}

Zavialov, A. ^{[7
]}

Lam, E. ^{[8
]}

Bozhkov, P. V. ^{[1
]}

机构：

[1] Swedish Univ Agr Sci, Dept Plant Biol & Forest Genet, Uppsala BioCtr, SE-75007 Uppsala, Sweden

[2] VIB, Dept Plant Syst Biol, Ghent, Belgium

[3] Univ Ghent, Dept Plant Biotechnol & Genet, B-9000 Ghent, Belgium

[4] VIB, Dept Med Prot Res, Ghent, Belgium

[5] Univ Ghent, Dept Biochem, B-9000 Ghent, Belgium

[6] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[7] Swedish Univ Agr Sci, Dept Mol Biol, Biomed Ctr, SE-75007 Uppsala, Sweden

[8] Rutgers State Univ, Dept Plant Biol & Pathol, New Brunswick, NJ 08903 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2011年 / 18卷 / 08期

基金：

瑞典研究理事会; 美国国家科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

metacaspase; substrate specificity; caspase; cell proliferation; protein aggregation; in vivo degradome; PROGRAMMED CELL-DEATH; LEISHMANIA-MAJOR METACASPASE; CASPASE-LIKE ACTIVITY; ARABIDOPSIS-THALIANA; REGULATES APOPTOSIS; TRYPANOSOMA-BRUCEI; CYSTEINE PROTEASES; YEAST METACASPASE; INVOLVEMENT; COACTIVATOR;

D O I：

10.1038/cdd.2011.66

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of the metacaspase function and molecular regulation during programmed cell death, stress and cell proliferation, as well as an analysis of the first metacaspase-mediated proteolytic pathway. To prevent further misapplication of caspase-specific molecular probes for measuring and inhibiting metacaspase activity, we provide a list of probes suitable for metacaspases. Cell Death and Differentiation (2011) 18, 1279-1288; doi:10.1038/cdd.2011.66; published online 20 May 2011

引用

页码：1279 / 1288

页数：10

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