Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions

被引：97

作者：

Stavraka, Chara ^{[1
]}

Rush, Hannah ^{[1
]}

Ross, Paul ^{[1
,2
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, Dept Med Oncol, Guys Canc, Great Maze Pond, London SE1 9RT, England

[2] Kings Coll Hosp NHS Fdn Trust, Dept Oncol, London, England

来源：

JOURNAL OF HEPATOCELLULAR CARCINOMA | 2019年 / 6卷

关键词：

cholangiocarcinoma; hepatocellular carcinoma; combined; genetics; molecular biology; treatment; mixed liver tumors; primary liver cancer; PRIMARY LIVER-CARCINOMA; LONG-TERM PROGNOSIS; SURGICAL-TREATMENT; CLINICAL-FEATURES; INTRAHEPATIC CHOLANGIOCARCINOMA; IMAGING FEATURES; MRI FEATURES; TRANSPLANTATION; RESECTION; TUMORS;

D O I：

10.2147/JHC.S159805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Combined hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary hepatic malignancy with significant histological and biological heterogeneity. It presents with more aggressive behavior and worse survival outcomes than either hepatocellular carcinoma or CC and remains a diagnostic challenge. An accurate diagnosis is crucial for its optimal management. Major hepatectomy with hilar node resection remains the mainstay of treatment in operable cases. Advances in the genetic and molecular characterization of this tumor will contribute to the better understanding of its pathogenesis and shape its future management.

引用

页码：11 / 21

页数：11

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