A key role of C5a/C5aR activation for the development of sepsis

被引：34

作者：

Riedemann, NC ^{[1
]}

Guo, RF ^{[1
]}

Ward, PA ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2003年 / 74卷 / 06期

关键词：

inflammation; complement; cytokines; LPS; innate immunity; antibody;

D O I：

10.1189/jlb.0403137

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent studies, evidence has been provided for complement activation early during the onset of experimental sepsis. Excessive production of the anaphylatoxin C5a thereby appears to elicit various harmful effects. Blockade of C5a or C5a receptor (C5aR) at the start of experimental sepsis has been demonstrated to greatly improve survival in rodents. There is evidence that C5a, during the onset of sepsis, enhances the production of various proinflammatory mediators in different cell types. Besides its known, other proinflammatory effects, recent work suggested an inhibitory role of C5a for innate-immune functions of phagocytic cells (phagocytosis, reactive oxygen species production, chemotaxis) during experimental sepsis. This review article provides an overview of the important role of C5a/C5aR activation for the onset and development of sepsis. J. Leukoc. Biol. 74: 966-970; 2003.

引用

页码：966 / 970

页数：5

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