Long non-coding RNA HOXD-AS1 in cancer

被引：47
作者：
Li, Lianlian [1 ]
Wang, Yong [2 ]
Zhang, Xiaoyu [1 ]
Huang, Qiwei [3 ]
Diao, Yutao [1 ]
Yin, Haipeng [1 ]
Liu, Hongyan [1 ]
机构：
[1] Shandong Acad Med Sci, Inst Basic Med, Jinan 250062, Shandong, Peoples R China
[2] Shandong Xinchuang Biotechnol Co LTD, Jinan 250102, Shandong, Peoples R China
[3] Shandong Lab Anim Ctr, Jinan 250002, Shandong, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2018年 / 487卷
关键词：
LncRNA; HOXD-AS1; Prognosis; Diagnosis; Biomarker; Therapeutic target; MOLECULAR-MECHANISMS; REGULATES PROLIFERATION; CELL-PROLIFERATION; LNCRNA HOXD-AS1; PROGRESSION; INVASION; STATISTICS; MIGRATION; CERNA;
D O I：
10.1016/j.cca.2018.10.002
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Cancer is one of the leading causes of death worldwide with a high risk of incidence and mortality. Long non coding RNAs (lncRNAs) have been shown to participate in various biological processes, including tumorigenesis and progression. The HOXD-AS1 (also known as HAGLR and Mdgt) gene is located between the HOXD1 and HOXD3 genes in the HOXD cluster and has been reported to play a critical role in the development and progression of cancers. This review summarizes the current knowledge on the biological functions and mechanisms of HOXD-AS1 in different human cancers, including bladder, cervical, colorectal, gastric, ovarian, and prostate cancers, glioma, hepatocellular carcinoma, melanoma, osteosarcoma, and non-small cell lung cancer. The aberrant expression of HOXD-AS1 in these cancers was related with clinical features of patients with cancers. HOXD-AS1 regulates the growth, invasion, and migration of tumor cells through different underlying mechanisms. In conclusion, HOXD-AS1 may be considered as a promising diagnostic/prognostic biomarker or a novel therapeutic target for cancers.
引用
收藏
页码：197 / 201
页数：5
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