Role of 5 HT2C receptors in the control of central dopamine function

Substantial evidence suggests that the functional status of the mesocorticolimbic dopamine (DA) system originating in the ventral tegmental area is under a phasic and tonic inhibitory control by the 5-HT system that acts by stimulating 5-HT2C receptor subtypes, Indeed, electrophysiological and biochemical data demonstrate that 5-HT2C receptor agonists decrease, whereas 5-HT2C receptor antagonists enhance, mesocorticolimbic DA function. However. 5-HT2C receptors do not appear to play a relevant role in the control of the nigrostriatal DA system originating in the substantia nigra pars compacta, In this article, the role of 5-HT2C receptors in the control of brain DA function will be reviewed, and the search for new therapies for neuropsychiatric disorders, such as depression, schizophrenia and drug addiction, based on these findings will be discussed.