After Hrs with HIV

被引：29

作者：

Amara, A

Littman, DR ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, Mol Pathogenesis Program, New York, NY 10016 USA

[2] NYU, Sch Med, Skirball Inst Biomol Med, Howard Hughes Med Inst, New York, NY 10016 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 162卷 / 03期

关键词：

D O I：

10.1083/jcb.200307062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To efficiently bud off from infected cells, HIV and other enveloped viruses hijack the host cellular machinery that is normally involved in vacuolar protein sorting and multi-vesicular body (MVB) biogenesis. The HIV Gag protein mimics hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a modular adaptor protein that links membrane cargo recognition to its degradation after delivery to MVBs. In contrast to T cells, where HIV budding occurs at the plasma membrane, virus buds into vacuoles of macrophages, a process that may facilitate its spread within the infected host.

引用

收藏

页码：371 / 375

页数：5

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