Apelin/APJ system: A novel therapeutic target for locomotor system diseases

被引：19

作者：

Luo, Jingshun ^{[1
]}

Liu, Wei ^{[2
]}

Feng, Fen ^{[3
]}

Chen, Linxi ^{[1
]}

机构：

[1] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 3, Dept Pharm, Changsha 410013, Peoples R China

[3] Shaoyang Univ, Sch Med, Shaoyang 422000, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2021年 / 906卷

基金：

中国国家自然科学基金;

关键词：

Apelin; APJ system; Locomotor system; Metabolism; Osteoarthritis; Osteoporosis; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; MESENCHYMAL STEM-CELLS; FATTY-ACID OXIDATION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; ENDOGENOUS LIGAND; AEROBIC EXERCISE; RECEPTOR; APJ;

D O I：

10.1016/j.ejphar.2021.174286

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Apelin is an endogenous ligand of G protein-coupled receptor APJ. Apelin/APJ system is widely expressed in abundant tissues, especially bone, joint and muscle tissue. This review focus on the effects of apelin/APJ system on locomotor system. An increasing number of evidence suggests that apelin/APJ system plays a crucial role in many physiological and pathological processes of locomotor system. Physiologically, apelin/APJ system promotes bone formation, muscle metabolism and skeletal muscle production. Pathologically, apelin/APJ system exacerbates osteoarthritis pathogenesis, whereas it alleviates osteoporosis. Besides, the level of apelin expression is regulated by different training modes, including continuous aerobic exercise, high-intensity interval training and resistance exercises. More importantly, exercise-induced apelin may be a potent pharmacological agent for the treatment of diseases and the regulation of physiological processes. Considering the pleiotropic effects of apelin on locomotor system, apelin/APJ system may be an important therapeutic target for locomotor system diseases.

引用

页数：9

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