Ecklonia cava fucoidan has potential to stimulate natural killer cells in vivo

被引：41

作者：

Zhang, Wei ^{[1
,2
]}

An, Eun-Koung ^{[3
,4
]}

Park, Hae-Bin ^{[1
,2
,3
,4
]}

Hwang, Juyoung ^{[1
,2
,3
,4
]}

Dhananjay, Yadav ^{[4
]}

Kim, So-Jung ^{[4
]}

Eom, Hee-Yun ^{[4
]}

Oda, Tatsuya ^{[5
]}

Kwak, Minseok ^{[6
]}

Lee, Peter Chang-Whan ^{[7
]}

Jin, Jun-O ^{[1
,2
,3
,4
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 201508, Peoples R China

[3] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, South Korea

[4] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea

[5] Nagasaki Univ, Fac Fisheries, Div Biochem, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan

[6] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea

[7] Univ Ulsan, Coll Med, ASAN Med Ctr, Dept Biomed Sci, Seoul, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 185卷

基金：

新加坡国家研究基金会;

关键词：

Ecklonia cava fucoidan; Splenic natural killer cell; Cytotoxicity; Anti-tumor effect; DENDRITIC CELLS; INTERFERON-GAMMA; NK CELLS; BIOLOGICAL-ACTIVITIES; IMMUNE-RESPONSES; GRANZYME-B; ACTIVATION; ADJUVANT; RECEPTOR; CD69;

D O I：

10.1016/j.ijbiomac.2021.06.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fucoidan is a sulfated polysaccharide, derived from various marine brown seaweeds, that has immunomodulatory effects. In this study, we analyzed the effects of five different fucoidans, which were extracted from Ascophyllum nodosum, Undaria pinnatifida, Macrocystis pyrifera, Fucus vesiculosus, and Ecklonia cava, on natural killer (NK) cell activation in mice. Among these, E. cava fucoidan (ECF) promoted an increase in the number of NK cells in the spleen and had the strongest effect on the activation of NK cells. Additionally, we observed that DC stimulation was required for NK cell activation and that ECF had the most potent effect on splenic dendritic cells (DC). Finally, ECF treatment effectively prevented infiltration of CT-26 carcinoma cells in the lungs of BALB/c mice in an NK cell dependent manner. Collectively, these results suggest that ECF could be a suitable candidate for enhancing NK cell-mediated anti-cancer immunity.

引用

页码：111 / 121

页数：11

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