3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione

被引：1

作者：

Uwabagira, Nadine ^{[1
]}

Sarojini, Balladka Kunhana ^{[1
,2
]}

机构：

[1] Mangalore Univ, Dept Studies Biochem, Div Biochem, Mangalore 574199, Karnataka, India

[2] Mangalore Univ, Dept Studies Ind Chem, Mangalore 574199, Karnataka, India

来源：

MOLBANK | 2019年 / 2019卷 / 04期

关键词：

antibreast cancer; anti-inflammator; hemolysis assay; thiazolidinedione; CDK; 2; THIAZOLIDINEDIONES;

D O I：

10.3390/M1083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The compound 3-{[(2,3-Dichlorophenyl)amino]methyl}-5-(furan-2-ylmethylidene)-1,3-thiazolidine-2,4-dione has been designed, synthesized, and screened for its in vitro antibreast cancer activity, using human breast adenocarcinoma cell lines (MCF-7) and in vitro anti-inflammatory activity. By hemolysis assay, it showed that it has a nonhemolytic and nontoxic effect on human blood cell. The title compound 5, subjected to in vitro activities, showed that it is cytotoxic with an IC50 of 42.30 mu M and a good anti-inflammatory agent. The docking results against cyclin dependent kinase 2 (CDK2) (PDB ID: 3QQK) gave insights on its inhibitory activity.

引用

页数：8

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