Molecular pathology in forensic medicine-Introduction

被引：37

作者：

Madea, Burkhard ^{[1
]}

Saukko, Pekka ^{[2
]}

Oliva, Antonio ^{[3
]}

Musshoff, Frank ^{[1
]}

机构：

[1] Univ Bonn, Inst Forens Med, D-53111 Bonn, Germany

[2] Univ Turku, Inst Forens Med, Turku, Finland

[3] Univ Cattolica Sacro Cuore, Inst Forens Med, Rome, Italy

来源：

FORENSIC SCIENCE INTERNATIONAL | 2010年 / 203卷 / 1-3期

关键词：

Molecular biology; Cause of death; Tissue identification; Gene expression; Evidential value; SUDDEN CARDIAC DEATH; ENDOTHELIAL GROWTH-FACTOR; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; LONG-QT SYNDROME; MESSENGER-RNA; METABOLITE RATIOS; UNEXPLAINED DEATH; RT-PCR; AUTOPSY; DIAGNOSIS;

D O I：

10.1016/j.forsciint.2010.07.017

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Techniques of molecular biology have improved diagnostic sensitivity, accuracy and validity in forensic medicine very much, especially in the field of identification (paternity testing, stain analysis). Since more than 10 years these techniques - meanwhile well established in clinical disciplines - are used also for other applications in forensic medicine: determination of cause and manner of death, tissue identification by mRNA and microRNA, examination of gene expression levels (survival time, time since death, cause of death), toxicogenetics. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：3 / 14

页数：12

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